Barcelona's shock 1-0 defeat at struggling Valladolid allowed Real Madrid to open up a three-point lead in La Liga as Manchester City were upset by Wigan Athletic in the English FA Cup for the second successive season.
Bayern Munich racked up their 16th successive win to close in on the Bundesliga title and Juventus moved 14 points clear at the top of Italy's Serie A with a 1-0 win over Fiorentina as their closest challengers AS Roma lost to Napoli.
Real Madrid punished Barcelona's shock reverse at lowly Real Valladolid with a 3-0 win at home to 10-man Levante on Sunday that put Carlo Ancelotti's in-form side three points clear at the top.
Cristiano Ronaldo, the leading scorer in Spain this season, took his tally to 24 goals when he headed the opener from Angel Di Maria's corner in the 11th minute and Marcelo added a second from Ronaldo's assist four minutes after the break.
David Navarro was harshly shown a straight red card in the 64th minute for an innocuous-looking tackle on Ronaldo and fellow Levante defender Nikos Karampelas put the ball into his own net nine minutes from time.
Real, unbeaten in 29 matches in all competitions, have 67 points with 11 matches left, with Atletico Madrid three behind in second after they won 2-0 at Celta Vigo on Saturday.
Champions Barca, who play at Real in the La Liga "Clasico" in two weeks time, turned in one of their worst performances of the campaign at Valladolid, who are battling relegation, and slipped to third on 63 points.
FA Cup holders Wigan Athletic pulled off another massive upset when they won 2-1 at Premier League title-chasing Manchester City to reach the semi-finals.
Second-tier Wigan, who shocked City in the final at Wembley last year, stormed into a 2-0 lead at the Etihad Stadium and although Samir Nasri pulled one back for the hosts they could not force an equaliser and their hopes of a quadruple of trophies this season were left in tatters.
Arsenal beat Everton 4-1 on Saturday and they and Wigan were joined in the last four by Sheffield United, who became the first third-tier team to reach the semis since 2001, and Hull City.
Substitute Demba Ba scored two late goals as Chelsea crushed Tottenham Hotspur 4-0 on Saturday to move seven points clear of Liverpool and Arsenal at the top of the Premier League table.
Chelsea have played a game more than their closest challengers