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In the NSE index, Infosys' weighting stands at 8.41 percent compared with 8.58 percent for ITC.
Software exporter Infosys share price rose 16.4 percent in the last 3 months on rupee depreciation and hopes of higher business from the United States, while ITC Ltd, a bet on domestic consumption, fell 11.7 percent in the same period on valuations and a slowing economy.
Infosys overtook Reliance Industries (RIL) as the stock with second-biggest weighting in the benchmark index in October.
Infosys Ltd shares were up 1.2 percent after earlier touching a record high of 3,557.60 rupees.