Basab Pradhan quit in July, the company's global manufacturing head Ashok Vemuri resigned in August to join rival iGate as CEO. Stephen Pratt, who co-founded Infosys consulting, had stepped down last month.
In September, Infosys Head of BPO sales in Australia Kartik Jayaraman and BPO Head Latin America Humberto Andrade had quit the company. A month earlier, its Vice President and Financial Services Head for the Americas Sudhir Chaturvedi quit.
Murthy, 67, has been making a series of changes at Infosys, including cutting costs at on-site work locations, and shifting focus to winning large outsourcing projects.
The top level exit also comes amidst organisational restructuring that company Executive Chairman N R Narayana Murthy is overseeing after returning to revive the sagging fortunes of the company in June.