The shock losses suffered by top two seeds Serena Williams and Li Na have left Maria Sharapova with a smooth passage and the Russian is primed to win her second Wimbledon title, 10 years after winning her first as a 17-year-old.
Sharapova has dropped just seven games in her three matches thus far and the imperious Russian will be confident of winning her sixth grand slam in the absence of her nemesis Williams.
The 27-year-old is on the wrong end of a 16-2 head-to-head record against the American with her only two triumphs coming in 2004, the first of which saw her crowned Wimbledon champion.
Williams crashed out 6-1 3-6 4-6 against France's Alize Cornet in the third round on Saturday, her earliest exit at Wimbledon since losing in the same round in 2005.
Her defeat came a day after Chinese two-times grand slam winner Na was dumped out 6-7(5) 6-7(5) by the Czech Republic's Barbora Zahlavova Strycova.
Their defeats have opened the door for a host of women, but the top of that list is Sharapova.
Players have long talked about the difficulty of adapting to the grasscourts of Wimbledon so soon after a long claycourt season and nobody has backed up winning the French Open with Wimbledon triumph since Williams in 2002.
Maria Sharapova reacts after defeating Alison Riske of the US in their women's singles tennis match at the Wimbledon. (Reuters)
Sharapova's form, however, suggests she can match that achievement and win her sixth grand slam in the process.
"Well, this is only my second time trying to do that. Of course, the transition, it's no secret, it's very difficult," she said after reeling off 11 consecutive games to beat Alison Riske 6-3 6-0 in the third round on Saturday.
"But I'm quite happy with the way I've gone about things so far.
"You never know what to expect. Each match poses its different challenges. I'm happy I've gone further than last year, erasing those memories and trying to form new ones.
"A Grand Slam stage, when you're playing for two weeks, seven matches within those two weeks, you're always kind of rolling with each round.
"Once you get to another (grand slam), one of the toughest things is you start from scratch, you start from the first match.
"Mentally that's always, you know, a bit more difficult because you achieve some great success, then you get on the train, come