Scientists closer to discovering fountain of youth

May 05 2014, 13:52 IST
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Scientists have taken a first of its kind atomic level look at the enzyme telomerase, which holds some secrets as to how we age. (Thinkstock) Scientists have taken a first of its kind atomic level look at the enzyme telomerase, which holds some secrets as to how we age. (Thinkstock)
SummaryScientists have taken a first of its kind atomic level look at 'telomerase', a finding that may unlock secrets to fountain of youth.

Scientists have taken a first of its kind atomic level look at the enzyme telomerase, a finding that may unlock the secrets to the fountain of youth.

Telomeres and the enzyme telomerase have been in the news recently due to their connection with ageing and cancer.

Telomeres are found at the ends of our chromosomes and are stretches of DNA which protect our genetic data, make it possible for cells to divide, and hold some secrets as to how we age - and also how we get cancer.

An analogy can be drawn between telomeres at the end of chromosomes and the plastic tips on shoelaces: the telomeres keep chromosome ends from fraying and sticking to each other, which would destroy or scramble our genetic information.

Each time one of our cells divides its telomeres get shorter. When they get too short, the cell can no longer divide and it becomes inactive or dies.

This shortening process is associated with ageing, cancer and a higher risk of death. The initial telomere lengths may differ between individuals.

"Telomerase is crucial for telomere maintenance and genome integrity," said Julian Chen, professor of chemistry and biochemistry at Arizona Sate University (ASU) and one of the project's senior authors.

Mutations that disrupt telomerase function have been linked to numerous human diseases that arise from telomere shortening and genome instability, said Chen.

"Despite the strong medical applications, the mechanism for telomerase holoenzyme (the most important unit of the telomerase complex) assembly remains poorly understood.

"We are particularly excited about this research because it provides, for the first time, an atomic level description of the protein-RNA interaction in the vertebrate telomerase complex," Chen said.

The study was published in the journal Nature Structural and Molecular Biology.

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